Three-component reaction of gem-difluorinated cyclopropanes with alkenes and B2pin2 for the synthesis of monofluoroalkenes

Borylative difunctionalization of alkenes has emerged as a powerful approach for synthesizing highly functionalized molecules. Herein, dual Cu/Pd-catalysed borylfluoroallylation of alkenes was smoothly achieved by using gem-difluorinated cyclopropanes and B(2)pin(2), providing the corresponding monofluoroalkene scaffolds in moderate to high yields with excellent stereoselectivity. Moreover, an array of synthetic building blocks can be obtained by downstream transformations.

Automated summary

The dual Cu/Pd catalyzed borylfluoroallylation of alkenes using gem-difluorinated cyclopropanes and B(2)pin(2) has been achieved with moderate to high yields and excellent stereoselectivity, providing monofluoroalkene scaffolds. A variety of synthetic building blocks can be obtained through downstream transformations.