Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 26, Pages 5788-5793Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob00863c
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Funding
- National Research Foundation (NRF) of Korea [2021R1A2C1003804]
- National Research Foundation of Korea [2021R1A2C1003804] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This paper reports the synthesis of two deoxyuridine derivatives functioning as molecular rotors, and demonstrates the utility of this probing system in sensing gene regulation arising from interactions between G-quadruplex and nucleolin.
In this paper we report the synthesis of two deoxyuridine derivatives (dU(CN2), dU(Py))-featuring p-vinylaniline-based fluorophores linked through a propargyl unit at the 5' position- that function as molecular rotors. This probing system proved to be useful for the sensing of gene regulation arising from interactions between this G-quadruplex and nucleolin.
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