Easy access to drug building-blocks through benzylic C-H functionalization of phenolic ethers by photoredox catalysis

A visible light-mediated photocatalyzed C-C-bond forming method for the benzylic C-H functionalization of phenolether containing synthetic building blocks based on a radical-cation/deprotonation strategy is reported. This method allows the mild, selective generation of benzyl radicals in phenolic complex molecules and drug-like compounds, providing new entries in synthetic and medicinal chemistry.

Automated summary

A visible light-mediated photocatalyzed C-C-bond forming method has been developed for the benzylic C-H functionalization of phenolether containing synthetic building blocks based on a radical-cation/deprotonation strategy. This method enables the mild, selective generation of benzyl radicals in phenolic complex molecules and drug-like compounds, offering new opportunities in synthetic and medicinal chemistry.