Journal
EXPERT REVIEW OF VACCINES
Volume 16, Issue 9, Pages 871-881Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14760584.2017.1355245
Keywords
Intrinsic adjuvanticity; innate immunity; antiviral response; type I interferon; delivery system; optimization; self-amplifying mRNA (SAM)
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Funding
- GlaxoSmithKline Biologicals SA
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Introduction: The present review summarizes the growing body of work defining the mechanisms of action of this exciting new vaccine technology that should allow rational approaches in the design of next generation mRNA vaccines. Areas covered: Bio-distribution of mRNA, localization of antigen production, role of the innate immunity, priming of the adaptive immune response, route of administration and effects of mRNA delivery systems. Expert commentary: In the last few years, the development of RNA vaccines had a fast growth, the rising number of proof will enable rational approaches to improving the effectiveness and safety of this modern class of medicine.
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