Journal
EXPERT REVIEW OF PROTEOMICS
Volume 14, Issue 10, Pages 931-939Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14789450.2017.1377613
Keywords
Venom; peptide; toxin; mass spectrometry; proteome; transcriptome
Categories
Funding
- Australian Research Council [DP160104025]
- Australian National Health & Medical Research Council
Ask authors/readers for more resources
Introduction: Animal venoms are complex chemical arsenals. Most venoms are rich in bioactive peptides with proven potential as research tools, drug leads and drugs.Areas covered: We review recent advances in venom-peptide discovery, particularly the adoption of combined transcriptomic/proteomic approaches for the exploration of venom composition.Expert commentary: Advances in transcriptomics and proteomics have dramatically altered the manner and rate of venom-peptide discovery. The increasing trend towards a toxin-driven approach, as opposed to traditional target-based screening of venoms, is likely to expedite the discovery of venom-peptides with novel structures and new and unanticipated mechanisms of action. At the same time, these advances will drive the development of higher-throughput approaches for target identification. Taken together, these approaches should enhance our understanding of the natural ecological function of venom peptides and increase the rate of identification of novel venom-derived pharmacological tools, drug leads and drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available