4.1 Review

Investigational drugs in recent clinical trials for treatment-resistant depression

Related references

Note: Only part of the references are listed.
Review Neurosciences

The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant

Joseph R. Moskal et al.

CURRENT NEUROPHARMACOLOGY (2017)

Review Neurosciences

Therapeutic Modulation of Glutamate Receptors in Major Depressive Disorder

Brittany A. Jaso et al.

CURRENT NEUROPHARMACOLOGY (2017)

Review Pharmacology & Pharmacy

Potential serotonergic agents for the treatment of schizophrenia

Ricardo P. Garay et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2016)

Editorial Material Psychiatry

Further Investigation of Ketamine

Robert Freedman

AMERICAN JOURNAL OF PSYCHIATRY (2016)

Article Immunology

Associations of low grade inflammation and endothelial dysfunction with depression - The Maastricht Study

Fleur E. P. van Dooren et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

Review Pharmacology & Pharmacy

Investigational drugs for treating agitation in persons with dementia

Ricardo P. Garay et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2016)

Article Medicine, General & Internal

Prescription of Long-Acting Opioids and Mortality in Patients With Chronic Noncancer Pain

Wayne A. Ray et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Article Psychology, Clinical

Assessing the Risk Factors for Difficult-to-Treat Depression and Treatment-Resistant Depression

Bradley Gaynes

JOURNAL OF CLINICAL PSYCHIATRY (2016)

Article Multidisciplinary Sciences

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Panos Zanos et al.

NATURE (2016)

Review Pharmacology & Pharmacy

Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders

Linda Nguyen et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Article Medicine, General & Internal

How to define treatment-resistant depression?

Jerome Holtzmann et al.

PRESSE MEDICALE (2016)

Editorial Material Medicine, General & Internal

The roadmap for therapeutic strategies of treatment resistant depression

Wissam El-Hage

PRESSE MEDICALE (2016)

Article Medicine, General & Internal

Resistant depression : other therapeutic strategies

Ghassen Saba et al.

PRESSE MEDICALE (2016)

Article Clinical Neurology

Role of glutamate receptors and glial cells in the pathophysiology of treatment-resistant depression

Yong-Ku Kim et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2016)

Letter Psychology, Clinical

R-ketamine: a rapid-onset and sustained antidepressant without risk of brain toxicity

K. Hashimoto

PSYCHOLOGICAL MEDICINE (2016)

Article Pharmacology & Pharmacy

Evaluating antidepressant treatment prior to adding second-line therapies among patients with treatment-resistant depression

Amany K. Hassan et al.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY (2016)

Article Psychology, Clinical

Sudden Gains in Cognitive-Behavior Therapy for Treatment-Resistant Depression: Processes of Change

Anna Abel et al.

JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY (2016)

Review Psychiatry

Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression

D. Jeffrey Newport et al.

AMERICAN JOURNAL OF PSYCHIATRY (2015)

Article Clinical Neurology

The promise of ketamine for treatment-resistant depression: current evidence and future directions

Kaitlin E. DeWilde et al.

AFFECTIVE DISORDERS AND TRAUMATIC BRAIN INJURY (2015)

Article Neurosciences

Treatment-resistant Late-life Depression: Challenges and Perspectives

Christian Knoechel et al.

CURRENT NEUROPHARMACOLOGY (2015)

Review Clinical Neurology

The preclinical profile of brexpiprazole: what is its clinical relevance for the treatment of psychiatric disorders?

Leslie Citrome et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2015)

Article Medicine, General & Internal

Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia A Randomized Clinical Trial

Jeffrey L. Cummings et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Editorial Material Medicine, General & Internal

Is ketamine ready to be used clinically for the treatment of depression?

Colleen Loo

MEDICAL JOURNAL OF AUSTRALIA (2015)

Article Multidisciplinary Sciences

Circulating interleukin-6 and cancer: A meta-analysis using Mendelian randomization

Geng Tian et al.

SCIENTIFIC REPORTS (2015)

Review Clinical Neurology

The preclinical profile of brexpiprazole: what is its clinical relevance for the treatment of psychiatric disorders?

Leslie Citrome et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2015)

Article Neurosciences

Evaluation of Opioid Modulation in Major Depressive Disorder

Elliot Ehrich et al.

NEUROPSYCHOPHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

Preclinical pharmacology and pharmacokinetics of CERC-301, a GluN2B-selective N-methyl-D-aspartate receptor antagonist

Rachel Garner et al.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2015)

Article Pharmacology & Pharmacy

The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition

Panos Zanos et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)

Review Pharmacology & Pharmacy

NMDA antagonists under investigation for the treatment of major depressive disorder

Bartlomiej Pochwat et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2014)

Review Clinical Neurology

Treatment-resistant depression: Definitions, review of the evidence, and algorithmic approach

Roger S. McIntyre et al.

JOURNAL OF AFFECTIVE DISORDERS (2014)

Article Clinical Neurology

C-reactive protein, interleukin-6, soluble tumor necrosis factor α receptor 2 and incident clinical depression

Patricia O. Chocano-Bedoya et al.

JOURNAL OF AFFECTIVE DISORDERS (2014)

Article Multidisciplinary Sciences

Involvement of Sigma-1 Receptors in the Antidepressant-like Effects of Dextromethorphan

Linda Nguyen et al.

PLOS ONE (2014)

Article Behavioral Sciences

R(-)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

Ji-chun Zhang et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2014)

Review Psychiatry

Emerging antidepressants to treat major depressive disorder

Samantha G. Block et al.

ASIAN JOURNAL OF PSYCHIATRY (2014)

Article Multidisciplinary Sciences

New paradigms for treatment-resistant depression

Carlos Zarate et al.

ANNALS REPORTS (2013)

Review Cell Biology

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Undine E. Lang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2013)

Review Clinical Neurology

CRP, IL-6 and depression: A systematic review and meta-analysis of longitudinal studies

Vyara Valkanova et al.

JOURNAL OF AFFECTIVE DISORDERS (2013)

Article Pharmacology & Pharmacy

Ketamine as a Novel Antidepressant: From Synapse to Behavior

J. W. Murrough

CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)

Review Pharmacology & Pharmacy

Treatment-emergent adverse events associated with atypical antipsychotics

Danielle S. Cha et al.

EXPERT OPINION ON PHARMACOTHERAPY (2012)

Review Clinical Neurology

Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study

Tsuyoshi Miyaoka et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2012)

Review Medicine, General & Internal

Treatment-resistant depression: therapeutic trends, challenges, and future directions

Khalid Saad Al-Harbi

PATIENT PREFERENCE AND ADHERENCE (2012)

Review Pharmacology & Pharmacy

The drugs don't work? antidepressants and the current and future pharmacological management of depression

Elizabeth Penn et al.

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (2012)

Review Pharmacology & Pharmacy

Drug safety evaluation of ziprasidone

Leslie Citrome

EXPERT OPINION ON DRUG SAFETY (2011)

Article Psychiatry

Treatment-Resistant Depression

Michael E. Thase

JOURNAL OF CLINICAL PSYCHIATRY (2011)

Review Neurosciences

Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens

Adam L. Halberstadt et al.

NEUROPHARMACOLOGY (2011)

Review Neurosciences

Stuck in a rut: rethinking depression and its treatment

Paul E. Holtzheimer et al.

TRENDS IN NEUROSCIENCES (2011)

Article Neurosciences

Validation of the Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ)

Gregory M. Chandler et al.

CNS NEUROSCIENCE & THERAPEUTICS (2010)

Review Chemistry, Medicinal

The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments

Rodrigo Machado-Vieira et al.

PHARMACEUTICALS (2010)

Review Clinical Neurology

σ-1 receptors in major depression and anxiety

Shrinivas K. Kulkarni et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2009)

Article Nursing

Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

Robert H. Howland

JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES (2009)

Review Medicine, Research & Experimental

Tocilizumab

Adith Venkiteshwaran

Article Psychiatry

Glutamate and the neural basis of the subjective effects of ketamine

J. F. William Deakin et al.

ARCHIVES OF GENERAL PSYCHIATRY (2008)

Article Psychiatry

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

Carlos A. Zarate et al.

ARCHIVES OF GENERAL PSYCHIATRY (2006)

Article Biochemistry & Molecular Biology

Determinants of trapping block of N-methyl-D-aspartate receptor channels

KV Bolshakov et al.

JOURNAL OF NEUROCHEMISTRY (2003)

Article Pharmacology & Pharmacy

Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile

AW Schmidt et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2001)