4.8 Review

Molecular oxygen-mediated oxygenation reactions involving radicals

Journal

CHEMICAL SOCIETY REVIEWS
Volume 50, Issue 14, Pages 8067-8101

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cs00242b

Keywords

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Funding

  1. National Natural Science Foundation of China [22001086, 21632001, 81821004]
  2. Fundamental Research Funds for the Central Universities (HUST) [2020kfyXJJS094]

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Molecular oxygen, as a green and non-toxic oxidant, offers various advantages in organic transformations for the synthesis of oxygen-containing compounds. Recent advances in radical processes using molecular oxygen as an oxidant have been discussed, along with reaction scopes, limitations, and mechanisms, providing insights for future developments in this field.
Molecular oxygen as a green, non-toxic and inexpensive oxidant has displayed lots of advantages compared with other oxidants towards more selective, sustainable, and environmentally benign organic transformations. The oxygenation reactions which employ molecular oxygen or ambient air as both an oxidant and an oxygen source provide an efficient route to the synthesis of oxygen-containing compounds, and have been demonstrated in practical applications such as pharmaceutical synthesis and late-stage functionalization of complex molecules. This review article introduces the recent advances of radical processes in molecular oxygen-mediated oxygenation reactions. Reaction scopes, limitations and mechanisms are discussed based on reaction types and catalytic systems. Conclusions and perspectives are also given in the end.

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