Journal
EXPERT REVIEW OF MEDICAL DEVICES
Volume 14, Issue 11, Pages 849-866Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17434440.2017.1389274
Keywords
Bioprosthetic heart valve; constitutive modeling; fluid-structure interaction; modeling and simulation; valve dynamics
Categories
Funding
- National Institute of Health [R01 HL119297, R01 HL63954]
- ICES Postdoctoral Fellowship
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Introduction: Replacement with a prosthetic device remains a major treatment option for the patients suffering from heart valve disease, with prevalence growing resulting from an ageing population. While the most popular replacement heart valve continues to be the bioprosthetic heart valve (BHV), its durability remains limited. There is thus a continued need to develop a general understanding of the underlying mechanisms limiting BHV durability to facilitate development of a more durable prosthesis. In this regard, computational models can play a pivotal role as they can evaluate our understanding of the underlying mechanisms and be used to optimize designs that may not always be intuitive.Areas covered: This review covers recent progress in computational models for the simulation of BHV, with a focus on aortic valve (AV) replacement. Recent contributions in valve geometry, leaflet material models, novel methods for numerical simulation, and applications to BHV optimization are discussed. This information should serve not only to infer reliable and dependable BHV function, but also to establish guidelines and insight for the design of future prosthetic valves by analyzing the influence of design, hemodynamics and tissue mechanics.Expert commentary: The paradigm of predictive modeling of heart valve prosthesis are becoming a reality which can simultaneously improve clinical outcomes and reduce costs. It can also lead to patient-specific valve design.
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