Journal
SCIENCE CHINA-MATERIALS
Volume 64, Issue 10, Pages 2613-2623Publisher
SCIENCE PRESS
DOI: 10.1007/s40843-021-1633-5
Keywords
photothermal therapy; near infrared; T-1 magnetic resonance imaging; thin-layered FePS3 nanosheets; bifunctional nanomedicine
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Funding
- National Key Research and Development Program of China [2017YFA0205302]
- Key Grant for Special Professors in Jiangsu Province [RK030STP18001]
- Key Research and Development Program of Jiangsu [BE2018732]
- Natural Science Key Fund for Colleges and Universities in Jiangsu Province [17KJA430011]
- National Postdoctoral Program for Innovative Talents [BX20190156]
- Scientific Research Foundation of Nanjing University of Posts and Telecommunications [NY218150]
- Training Program of the Major Research Plan of the National Natural Science Foundation of China from Nanjing University of Posts and Telecommunications [NY218158]
- 1311 Talents Program of Nanjing University of Posts and Telecommunications
- 100 Top Talents Program of Sun Yat-sen University [29000-18841216]
- Young-Teacher Training Program of Sun Yat-sen University [29000-31610036]
- Joint Funds for the Innovation of Science and Technology in Fujian Province [2017Y9111]
- Natural Science Foundation of Fujian Province [2020J01613]
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The study successfully synthesized FePS3-PEG nanosheets with excellent photothermal conversion efficiency and magnetic resonance imaging effects, making them promising for T-1 weighted MRI-guided near-infrared photothermal therapy for cancer treatment.
Developing bifunctional nanoplatforms integrating advanced biological imaging with high-performance therapeutic functions is interesting for nanoscience and biomedicine. Herein, thin-layered FePS3 nanosheets modified with amine polyethylene glycol (FePS3-PEG) are synthesized by ultrasonicated exfoliation of bulk FePS3 single crystals under Ar atmosphere and in situ chemical functionalization with amine PEG. The prepared FePS3-PEG nanosheets give a photothermal conversion efficiency of 22.1% under 808-nm laser and evident T-1 relaxation (r(1) = 2.69 (mmol L-1)(-1) S-1) in external magnetic fields. Biologically experimental results in vitro and in vivo demonstrate that FePS3-PEG nanosheets have good biocompatibility and exhibit excellent photothermal therapy (PTT) effect under clear T-1 weighted magnetic resonance imaging (MRI). The characteristics of FePS3-PEG nanosheets enable them to be a promising nanomedicine for T-1-weighted MRI-guided near-infrared PTT of cancers.
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