Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 53, Pages 6499-6502Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01955d
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Funding
- National Natural Science Foundation of China [21675142]
- Leading Talent Program of Science and Technology Innovation in Zhejiang [2020R52022]
- Key Project of Natural Science Foundation of Zhejiang Province [LZ20B050001]
- Independent Designing Scientific Research Project of Zhejiang Normal University [2020ZS0304]
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POH3 is designed to specifically bind with triplex DNA, resulting in a turn-on fluorescence response, and can be developed into a catalytic triplex DNAzyme for porphyrin metalation. The catalytic activity is initiated by the enhanced basicity of POH3 upon binding with the triplex DNA.
Trihydroxyphenyl porphyrin (POH3) was designed to specifically bind with a triplex DNA resulting in a turn-on fluorescence response. This ensemble can be developed into a catalytic triplex DNAzyme towards porphyrin metalation. The catalytic activity is initiated by the enhanced basicity of POH3 upon binding with the triplex DNA.
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