Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 53, Pages 6487-6490Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00787d
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Funding
- NSFC [21635003, 21811540027, 21974048, 22022402]
- Program of Shanghai Subject Chief Scientist [15XD1501600]
- Innovation Program of Shanghai Municipal Education Commission [201701070005E00020]
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An electrochemical method was reported for selectively sensing and accurately quantifying monoamine oxidase A (MAO-A) in the cortex and thalamus of a live mouse brain. Using this tool, it was found that MAO-A increased Ca2+ entry into neurons via the TPRM2 channel in the live mouse brain of an AD model.
Herein, an electrochemical method for selectively sensing and accurately quantifying monoamine oxidase A (MAO-A) in the cortex and thalamus of a live mouse brain was reported. Using this tool, it was found that MAO-A increased Ca2+ entry into neurons via the TPRM2 channel in the live mouse brain of an AD model.
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