Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 53, Pages 6558-6561Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01847g
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Funding
- National Natural Science Foundation of China [21877115, 21635008, 21874140]
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NST is a blue light activated anti-cancer prodrug that shows minimal cytotoxicity in the dark but exhibits high cytotoxicity through photocleavage upon irradiation.
A blue light activated anti-cancer prodrug, NST, was designed based on a photoactive 4-aminonaphthalimide derivative and an anticancer drug, 10-hydroxycamptothecin. NST was hard to be taken up by living cells and showed negligible dark cytotoxicity. The irradiation caused photocleavage of NST and resulted in high cytotoxicity.
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