Can a Biohybrid Patch Salvage Ventricular Function at a Late Time Point in the Post-Infarction Remodeling Process?

A biohybrid patch without cellular components was implanted over large infarcted areas in severely dilated hearts. Nonpatched animals were assigned to control or losartan therapy. Patch-implanted animals responded with better morphological and functional echocardiographic endpoints, which were more evident in a subgroup of animals with very tow pre-treatment ejection fraction (<35%). Patched animals also had smaller infarcts than both nonpatched groups. This simple approach could hold promise for clinical translation and be applied using minimally invasive procedures over the epicardium in a large set of patients to induce better ventricular remodeling, especially among those who are especially frail. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

Automated summary

Implanting a biohybrid patch without cellular components over large infarcted areas in severely dilated hearts resulted in better morphological and functional echocardiographic endpoints, especially in animals with very low pre-treatment ejection fraction. The patched animals also had smaller infarcts compared to nonpatched groups. This simple approach shows promise for clinical translation and may be particularly beneficial for patients with frailty.