Journal
NATURE REVIEWS METHODS PRIMERS
Volume 1, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s43586-021-00041-2
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [SPP 1807]
- Onassis Foundation
- European Union [720996, 860762]
- National Science Foundation (NSF) [CHE-1700982]
- Maurice Wilkins Centre for Molecular Biodiscovery
- ANR-DFG programme [ANR-17-CE07-0049-01]
- MEXT [17H06091]
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C-H activation has emerged as a powerful platform for molecular syntheses in various fields including natural product syntheses, pharmaceutical industries, and material sciences. This Primer summarizes best practices for experimental set-up, data deposition, and key developments in C-H activation, as well as discussing its applications and limitations.
Transition metal-catalysed C-H activation has emerged as an increasingly powerful platform for molecular syntheses, enabling applications to natural product syntheses, late-stage modification, pharmaceutical industries and material sciences, among others. This Primer summarizes representative best practices for the experimental set-up and data deposition for C-H activation, as well as discussing key developments including recent advances in asymmetric, photoinduced and electrocatalytic C-H activation. Likewise, strategies for applications of C-H activation towards the assembly of structurally complex (bio)polymers and drugs in academia and industry are discussed. In addition, current limitations in C-H activation and possible approaches for overcoming these shortcomings are reviewed.
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