Related references
Note: Only part of the references are listed.Chemical Inhibitors of Epigenetic Methyllysine Reader Proteins
Natalia Milosevich et al.
BIOCHEMISTRY (2016)
Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B
Peiling Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF
James Bennett et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition
Natalie H. Theodoulou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor
Wylie S. Palmer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family
Natalia Milosevich et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
Bromodomains: Structure, function and pharmacology of inhibition
Elena Ferri et al.
BIOCHEMICAL PHARMACOLOGY (2016)
A Druggable TCF4-and BRD4-Dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm
Michele Ceribelli et al.
CANCER CELL (2016)
Chemical genetics approaches for selective intervention in epigenetics
Andrew C. Runcie et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2016)
Chemical probes for methyl lysine reader domains
Lindsey I. James et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2016)
New insights into the role of the Brdt protein in the regulation of development and spermatogenesis in the mouse
Shimi Barda et al.
GENE EXPRESSION PATTERNS (2016)
Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
Laetitia J. Martin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials
Brian K. Albrecht et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
Yuanyuan Li et al.
MOLECULAR CELL (2016)
A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
Jacob I. Stuckey et al.
NATURE CHEMICAL BIOLOGY (2016)
Insights into newly discovered marks and readers of epigenetic information
Forest H. Andrews et al.
NATURE CHEMICAL BIOLOGY (2016)
The Taf14 YEATS domain is a reader of histone crotonylation
Forest H. Andrews et al.
NATURE CHEMICAL BIOLOGY (2016)
Twenty years on: the impact of fragments on drug discovery
Daniel A. Erlanson et al.
NATURE REVIEWS DRUG DISCOVERY (2016)
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
Andrew P. Feinberg et al.
NATURE REVIEWS GENETICS (2016)
Targeting the cancer epigenome for therapy
Peter A. Jones et al.
NATURE REVIEWS GENETICS (2016)
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation
Eric Metzger et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform
Tobias Wagner et al.
NUCLEIC ACIDS RESEARCH (2016)
Epigenetic balance of gene expression by Polycomb and COMPASS families
Andrea Piunti et al.
SCIENCE (2016)
Chemical probes and inhibitors of bromodomains outside the BET family
Moses Moustakim et al.
MEDCHEMCOMM (2016)
GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
Paul Bamborough et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation
Eric Metzger et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb
Panpan Lu et al.
SCIENTIFIC REPORTS (2016)
NanoBRET-A Novel BRET Platform for the Analysis of Protein-Protein Interactions
Thomas Machleidt et al.
ACS CHEMICAL BIOLOGY (2015)
LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor
Peter G. K. Clark et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Sarah Picaud et al.
CANCER RESEARCH (2015)
Quantitative Proteomic Analysis of Histone Modifications
He Huang et al.
CHEMICAL REVIEWS (2015)
Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain
Chunyan Ren et al.
CHEMISTRY & BIOLOGY (2015)
The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs
Michela Boi et al.
CLINICAL CANCER RESEARCH (2015)
The interplay of histone modifications - writers that read
Tianyi Zhang et al.
EMBO REPORTS (2015)
Open access chemical probes for epigenetic targets
Peter J. Brown et al.
FUTURE MEDICINAL CHEMISTRY (2015)
Targeting bromodomain-containing protein 4 (BRD4) benefits rheumatoid arthritis
Qing-gang Zhang et al.
IMMUNOLOGY LETTERS (2015)
Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B
Ludovic Drouin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation
Benjamin R. Sabari et al.
MOLECULAR CELL (2015)
The promise and peril of chemical probes
Cheryl H. Arrowsmith et al.
NATURE CHEMICAL BIOLOGY (2015)
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses
Ariane Hammitzsch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Structural diversity of the epigenetics pocketome
Alexandre Cabaye et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2015)
Lessons from Hot Spot Analysis for Fragment-Basec Drug Discovery
David R. Hall et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery
Yanai Zhan et al.
EPIGENETICS & CHROMATIN (2015)
The histone code reader SPIN1 controls RET signaling in liposarcoma
Henriette Franz et al.
ONCOTARGET (2015)
Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression
Janneke G. C. Peeters et al.
CELL REPORTS (2015)
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance
Oleg Fedorov et al.
SCIENCE ADVANCES (2015)
Competitive Binding of a Benzimidazole to the Histone-Binding Pocket of the Pygo PHD Finger
Thomas C. R. Miller et al.
ACS CHEMICAL BIOLOGY (2014)
Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors
Stuart W. J. Ember et al.
ACS CHEMICAL BIOLOGY (2014)
Interpreting the language of histone and DNA modifications
Scott B. Rothbart et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2014)
Selective Chemical Modulation of Gene Transcription Favors Oligodendrocyte Lineage Progression
Mar Gacias et al.
CHEMISTRY & BIOLOGY (2014)
Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1
Xiaonan Su et al.
GENES & DEVELOPMENT (2014)
Chromodomain Antagonists That Target the Polycomb-Group Methyllysine Reader Protein Chromobox Homo log 7 (CBX7)
Chakravarthi Simhadri et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Minimalist Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling
Zhengqiu Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains
Duncan A. Hay et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Genome-wide localization of small molecules
Lars Anders et al.
NATURE BIOTECHNOLOGY (2014)
Dual kinase-bromodomain inhibitors for rationally designed polypharmacology
Pietro Ciceri et al.
NATURE CHEMICAL BIOLOGY (2014)
The cellular thermal shift assay for evaluating drug target interactions in cells
Rozbeh Jafari et al.
NATURE PROTOCOLS (2014)
Targeting bromodomains: epigenetic readers of lysine acetylation
Panagis Filippakopoulos et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
Matthias G. J. Baud et al.
SCIENCE (2014)
Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
Ramzi F. Sweis et al.
ACS MEDICINAL CHEMISTRY LETTERS (2014)
1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain
Emmanuel H. Demont et al.
ACS MEDICINAL CHEMISTRY LETTERS (2014)
Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains
Mathew P. Martin et al.
ACS CHEMICAL BIOLOGY (2013)
4-Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading
Xavier Lucas et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition
Feng Wang et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2013)
Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain
Fleur M. Ferguson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3
Lindsey I. James et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
Guangtao Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
Lindsey I. James et al.
NATURE CHEMICAL BIOLOGY (2013)
Target validation using chemical probes
Mark E. Bunnage et al.
NATURE CHEMICAL BIOLOGY (2013)
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
Sarah Picaud et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Lysine methylation: beyond histones
Xi Zhang et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2012)
Pathogenesis of NUT Midline Carcinoma
Christopher A. French
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 7 (2012)
Identification and Characterization of Small Molecule Inhibitors of a Plant Homeodomain Finger
Elise K. Wagner et al.
BIOCHEMISTRY (2012)
ChromoHub: a data hub for navigators of chromatin-mediated signalling
Lihua Liu et al.
BIOINFORMATICS (2012)
Small-Molecule Inhibition of BRDT for Male Contraception
Martin M. Matzuk et al.
CELL (2012)
Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
Panagis Filippakopoulos et al.
CELL (2012)
Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites
Lewis R. Vidler et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit
Paul V. Fish et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Epigenetic protein families: a new frontier for drug discovery
Cheryl H. Arrowsmith et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors
Hozefa S. Bandukwala et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1
Na Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Jake E. Delmore et al.
CELL (2011)
Recognition and Specificity Determinants of the Human Cbx Chromodomains
Lilia Kaustov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Druggability of methyl-lysine binding sites
C. Santiago et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2011)
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Johannes Zuber et al.
NATURE (2011)
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
Mark A. Dawson et al.
NATURE (2011)
Targeting MYC dependence in cancer by inhibiting BET bromodomains
Jennifer A. Mertz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Interaction of Propionylated and Butyrylated Histone H3 Lysine Marks with Brd4 Bromodomains
Friederike Vollmuth et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Suppression of inflammation by a synthetic histone mimic
Edwige Nicodeme et al.
NATURE (2010)
Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b
Lei Zeng et al.
NATURE (2010)
Selective inhibition of BET bromodomains
Panagis Filippakopoulos et al.
NATURE (2010)
The art of the chemical probe
Stephen V. Frye
NATURE CHEMICAL BIOLOGY (2010)
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
Gang G. Wang et al.
NATURE (2009)
Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300
Lei Zeng et al.
STRUCTURE (2008)
Multivalent engagement of chromatin modifications by linked binding modules
Alexander J. Ruthenburg et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
Sean D. Taverna et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Target structure-based discovery of small molecules that block human p53 and CREB binding protein association
Sachchidanand et al.
CHEMISTRY & BIOLOGY (2006)
Double chromodomains cooperate to recognize the methylated histone H3 tail
JF Flanagan et al.
NATURE (2005)
CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus
D Bernard et al.
ONCOGENE (2005)
HIV-1 Tat interactions with p300 and PCAF transcriptional coactivators inhibit histone acetylation and neurotrophin signaling through CREB
KS Wong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
L Zeng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Share Paper
