Recent trends in biocatalysis

Biocatalysis has undergone revolutionary progress in the past century. Benefited by the integration of multidisciplinary technologies, natural enzymatic reactions are constantly being explored. Protein engineering gives birth to robust biocatalysts that are widely used in industrial production. These research achievements have gradually constructed a network containing natural enzymatic synthesis pathways and artificially designed enzymatic cascades. Nowadays, the development of artificial intelligence, automation, and ultra-high-throughput technology provides infinite possibilities for the discovery of novel enzymes, enzymatic mechanisms and enzymatic cascades, and gradually complements the lack of remaining key steps in the pathway design of enzymatic total synthesis. Therefore, the research of biocatalysis is gradually moving towards the era of novel technology integration, intelligent manufacturing and enzymatic total synthesis.

Automated summary

Biocatalysis has made revolutionary progress in the past century, benefiting from the integration of multidisciplinary technologies and the development of robust biocatalysts through protein engineering. The network of natural enzymatic synthesis pathways and artificially designed enzymatic cascades have been gradually constructed. Future development will move towards the integration of new technologies, intelligent manufacturing, and enzymatic total synthesis.