Applications of pyrazolone in multicomponent reactions for the synthesis of dihydropyrano[2,3-c]pyrazoles and spiro-pyrano[2,3-c]pyrazoles in aqueous medium

Pyrazolone is an important class of heterocyclic compounds with numerous applications in the fields of organic/material/pharmaceutical chemistry, food/textile industry and cosmetics. Because of these importances, the synthesis of biologically active complex molecules by employing pyrazolone has emerged. Dihydropyrano[2,3-c]pyrazoles and spiro-pyrano[2,3-c]pyrazoles are synthesized from pyrazolone and hold huge potential in the field of medicinal chemistry because of their wide-ranging biological activities. This review article will summarize the up to date advances on the application of pyrazolone in multicomponent reactions for the synthesis of dihydro- and spiro-pyrano[2,3-c]pyrazoles in aqueous medium. [GRAPHICS]

Automated summary

Pyrazolone is an important class of heterocyclic compounds with various applications in organic/material/pharmaceutical chemistry, food/textile industry, and cosmetics. The synthesis of biologically active complex molecules by employing pyrazolone has emerged, with dihydropyrano[2,3-c]pyrazoles and spiro-pyrano[2,3-c]pyrazoles holding huge potential in medicinal chemistry due to their wide-ranging biological activities. This review article summarizes recent advances on the application of pyrazolone in multicomponent reactions for the synthesis of dihydro- and spiro-pyrano[2,3-c]pyrazoles in aqueous medium.