Journal
ACTA DERMATO-VENEREOLOGICA
Volume 101, Issue -, Pages -Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-3824
Keywords
keratoacanthoma; epidemiology; keratoacanthoma; aetiology; surveys and questionnaires; ultraviolet rays; derma; tological surgical procedures
Categories
Funding
- Swedish Society for Medical Research [P160020]
- Swedish Society of Medicine [SLS685281]
- Gothenburg Society of Medicine [SLS687351]
- Hudfonden [2665]
- Sahlgrenska University Hospital Foundation
- National Health and Medical Research Council of Australia (NHMRC) [GNT1155413, GNT1073898, GNT1185416]
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This study from Queensland, Australia, aimed to describe the characteristics of keratoacanthomas in patients, their treatment patterns, and tumor features. The study found that most patients were male, aged 60 or above, with fair skin, and a history of actinic keratoses/keratinocyte cancers. Keratoacanthomas were commonly located on legs/feet, with excision being the most frequently used surgical method. Histopathological regression was reported in 67% of cases, suggesting potential for spontaneous resolution.
Keratoacanthomas are common keratinocyte skin tumours. However, there is little community-based data published on the clinical features of keratoacanthoma. The aim of this study was to describe the patient and tumour characteristics of keratoacanthomas, as well as their treatment patterns. Data were obtained from the QSkin Sun and Health study, a prospective cohort of 40,438 randomly sampled and consented participants aged 40-69 years in Queensland, Australia. In 2010, a baseline survey collected data, including demography, phenotype, ultraviolet radia tion exposure, medical history and lifestyle. Histo pathological reports of keratoacanthomas arising until 30 June 2014 were reviewed. In total, 584 participants developed 738 keratoacanthomas; 18% of participants developed multiple tumours. Common patient characteristics were male sex (58%), age >= 60 years (76%), fair skin (80%), and previous history of actinic keratoses/keratinocyte cancers (89%). Keratoacanthomas were commonly located on the legs/feet (48%), and rarely on the the head/neck (7%). Excision was the most frequently used surgical method (71%) Evidence of histopathological regression was reported in 67% of keratoacanthomas, suggesting a potential for spontan eous resolution in a significant proportion of keratoacanthomas.
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