Journal
CANCER BIOLOGY & MEDICINE
Volume 18, Issue 2, Pages 437-457Publisher
CHINA ANTI-CANCER ASSOC
DOI: 10.20892/j.issn.2095-3941.2020.0348
Keywords
Circular RNA; gastrointestinal malignancies; biological function; clinical value; digestive system
Categories
Funding
- National Natural Science Foundation of China [81702367, 81772279]
- Medical and Health Research Project of Zhejiang Province [2018KY159]
- Affiliated Hospital of Medical School of Ningbo University Youth Talent Cultivation Program [FYQMKY202001]
- Scientific Innovation Team Project of Ningbo [2017C110019]
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Circular RNAs (circRNAs) are endogenous RNA molecules produced by alternative splicing, which play important roles in the proliferation, differentiation, invasion, and metastasis of cancer cells through various mechanisms. They are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies.
Circular RNAs (circRNAs), a class of endogenous RNA molecules, are produced by alternative splicing of precursor RNA and are covalently linked at the 5' and 3' ends. Recent studies have revealed that dysregulated circRNAs are closely related to the occurrence and progression of gastrointestinal malignancies. Accumulating evidence indicates that circRNAs, including circPVT1, circLARP4, circ-SFMBT2, cir-ITCH, circRNA_100782, circ_100395, circ-DONSON, hsa_circ_0001368, circNRIP1, circFAT1(e2), circCCDC66, circSMARCA5, circ-ZNF652, and circ 0030235 play important roles in the proliferation, differentiation, invasion, and metastasis of cancer cells through a variety of mechanisms, such as acting as microRNA sponges, interacting with RNA-binding proteins, regulating gene transcription and alternative splicing, and being translated into proteins. With the characteristics of high abundance, high stability, extensive functions, and certain tissue-, time- and disease-specific expressions, circRNAs are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies.
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