Metal-free oxidative cyclization of trifluoroacetimidohydrazides with methylhetarenes: a facile access to 3-hetaryl-5-trifluoromethyl-1,2,4-triazoles

A metal-free oxidative cyclization of trifluoroacetimidohydrazides with methylhetarenes for the efficient synthesis of 3-hetaryl-5-trifluoromethyl-1,2,4-triazoles has been developed. Notable features of this protocol include readily accessible starting materials, a broad substrate scope, high efficiency and scalability. The transformation provides a facile and straightforward route to valuable multi-functionalized 1,2,4-triazole derivatives.

Automated summary

A metal-free oxidative cyclization of trifluoroacetimidohydrazides with methylhetarenes has been developed for the efficient synthesis of 3-hetaryl-5-trifluoromethyl-1,2,4-triazoles. This protocol features readily accessible starting materials, a broad substrate scope, high efficiency, and scalability, providing a facile and straightforward route to valuable multi-functionalized 1,2,4-triazole derivatives.