Journal
EXPERIMENTAL NEUROLOGY
Volume 287, Issue -, Pages 423-434Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2016.01.020
Keywords
Axon regeneration; Neurite outgrowth; In vitro models; Cell based assays; Organotypic assays; High content screening
Categories
Funding
- National Institute of Child Health and Human Development [HD057632]
- National Institute of Neurological Disorders and Stroke [NS080145]
- Miami Project to Cure Paralysis
- Walter G. Ross Foundation
Ask authors/readers for more resources
A variety of in vitro models have been developed to understand the mechanisms underlying the regenerative failure of central nervous system (CNS) axons, and to guide pre-clinical development of regeneration-promoting therapeutics. These range from single-cell based assays that typically focus on molecular mechanisms to organotypic assays that aim to recapitulate in vivo behavior. By utilizing a combination of models, researchers can balance the speed, convenience, and mechanistic resolution of simpler models with the biological relevance of more complex models. This review will discuss a number of models that have been used to build our understanding of the molecular mechanisms of CNS axon regeneration. (C) 2016 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available