Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 54, Pages 6604-6607Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01819a
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Funding
- National Natural Science Foundation of China [21874085, 21775091]
- Key Research and Development Program of Shandong Province [2018YFJH0502]
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The novel double-locked probe DCO-H2S-V is able to detect hydrogen sulfide in highly viscous systems, demonstrating effective activation and fluorescence emission only when H2S and high viscosity coexist in a cell. It has successfully been used to detect changes in viscosity and H2S in a Parkinson's disease model.
A novel double-locked probe, DCO-H2S-V, was prepared for detecting hydrogen sulfide in a highly viscous system. Experiments demonstrated that only when H2S and a high viscosity environment coexist in a cell, can the probe be activated effectively and emit fluorescence. This has been successfully used for detecting the changes in viscosity and H2S in a Parkinson's disease model, PC-12 cells treated with glutamate.
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