Related references
Note: Only part of the references are listed.Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways
Haonan Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Oridonin Ameliorates Lipopolysaccharide-Induced Endometritis in Mice via Inhibition of the TLR-4/NF-Bpathway
Min Zhou et al.
INFLAMMATION (2019)
ROS/JNK/c-Jun axis is involved in oridonin-induced caspase-dependent apoptosis in human colorectal cancer cells
Di Zhang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
Synthesis, and evaluation of in vitro and in vivo anticancer activity of 14-substituted oridonin analogs: A novel and potent cell cycle arrest and apoptosis inducer through the p53-MDM2 pathway
Qing-Kun Shen et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation
Xu Hu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Oridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling
Bili Wang et al.
ONCOTARGETS AND THERAPY (2019)
Hydrogen sulfide donating ent-kaurane and spirolactone-type 6,7-seco-ent-kaurane derivatives: Design, synthesis and antiproliferative properties
Haonan Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
被撤回的出版物: Oridonin elevates sensitivity of ovarian carcinoma cells to cisplatin via suppressing cisplatin-mediated autophagy (Retracted article. See vol. 304, 2022)
Yaxian Zhao et al.
LIFE SCIENCES (2019)
Homoharringtonine synergy with oridonin in treatment of t(8;21) acute myeloid leukemia
Weina Zhang et al.
FRONTIERS OF MEDICINE (2019)
A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3
Xiaofei Shen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Platinum Resistance in Ovarian Cancer: Role of DNA Repair
Giovanna Damia et al.
CANCERS (2019)
Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death
Wei Zheng et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Effects of dietary supplementation with oridonin on the growth performance, relative organ weight, lymphocyte proliferation, and cytokine concentration in broiler chickens
Qiu Jue Wu et al.
BMC VETERINARY RESEARCH (2018)
Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis
Dengfeng Li et al.
CANCER LETTERS (2018)
Oridonin inhibits vascular inflammation by blocking NF-kappa B and MAPK activation
Weichen Huang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2018)
Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-κB signaling pathways
Jushuang Li et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2018)
A Novel Diterpenoid Suppresses Osteoclastogenesis and Promotes Osteogenesis by Inhibiting Ifrd1-Mediated and IB-Mediated p65 Nuclear Translocation
Zi'ang Xie et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2018)
Design and synthesis of novel oridonin analogues as potent anticancer agents
Qing-Kun Shen et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)
Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads
Ye Ding et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Antifibrosis Effect of Novel Oridonin Analog CYD0618 Via Suppression of the NF-κB Pathway
Claire B. Cummins et al.
JOURNAL OF SURGICAL RESEARCH (2018)
Arsenic trioxide induces apoptosis and inhibits the growth of human liver cancer cells
Nadra Sadaf et al.
LIFE SCIENCES (2018)
Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection
Jimin Xu et al.
MOLECULES (2018)
Phytochemicals as inhibitors of NF-kappa B for treatment of Alzheimer's disease
Ean-Jeong Seo et al.
PHARMACOLOGICAL RESEARCH (2018)
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
Hongbin He et al.
NATURE COMMUNICATIONS (2018)
Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by in Silico and in Vitro Analyses
Onat Kadioglu et al.
FRONTIERS IN PHARMACOLOGY (2018)
Oridonin prevents epithelial-mesenchymal transition and TGF-β1-induced epithelial-mesenchymal transition by inhibiting TGF-β1/Smad2/3 in osteosarcoma
Yang Sun et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2018)
Oridonin Enhances Radiation-Induced Cell Death by Promoting DNA Damage in Non-Small Cell Lung Cancer Cells
Hyejin Park et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Effects of oridonin on immune cells, Th1/Th2 balance and the expression of BLys in the spleens of broiler chickens challenged with Salmonella pullorum
Qiu Jue Wu et al.
RESEARCH IN VETERINARY SCIENCE (2018)
Geridonin, a novel derivative of oridonin, inhibits proliferation of MGC 803 cells both in vitro and in vivo through elevating the intracellular ROS
Sai-Qi Wang et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2017)
A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway
Shengtao Xu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
6,7-Seco-ent-Kauranoids Derived from Oridonin as Potential Anticancer Agents
Shengtao Xu et al.
JOURNAL OF NATURAL PRODUCTS (2017)
Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins
Xiao-Hui Wang et al.
TUMOR BIOLOGY (2017)
Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs
Jiancheng Zhou et al.
CELL DEATH & DISEASE (2017)
Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells
Zhuo Yao et al.
CELL DEATH & DISEASE (2017)
Oridonin induces apoptosis and reverses drug resistance in cisplatin resistant human gastric cancer cells
Zhongwei He et al.
ONCOLOGY LETTERS (2017)
Oridonin synergistically enhances JQ1-triggered apoptosis in hepatocellular cancer cells through mitochondrial pathway
Hua-Peng Zhang et al.
ONCOTARGET (2017)
Oridonin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-induced RAW264.7 cells and acute lung injury
Gan Zhao et al.
ONCOTARGET (2017)
Synergistic suppression of t(8;21)-positive leukemia cell growth by combining oridonin and MAPK1/ERK2 inhibitors
Pavel Spirin et al.
ONCOTARGET (2017)
Oridonin effectively reverses the drug resistance of cisplatin involving induction of cell apoptosis and inhibition of MMP expression in human acute myeloid leukemia cells
Yuan Zhang et al.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2017)
Natural products to prevent drug resistance in cancer chemotherapy: a review
Renyikun Yuan et al.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)
A novel combination of oridonin and valproic acid in enhancement of apoptosis induction of HL-60 leukemia cells
Meiyan Shi et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2016)
Inhibition of nuclear factor κB transcription activity drives a synergistic effect of cisplatin and oridonin on HepG2 human hepatocellular carcinoma cells
Xinjun Dong et al.
ANTI-CANCER DRUGS (2016)
Novel nitric oxide-releasing spirolactone-type diterpenoid derivatives with in vitro synergistic anticancer activity as apoptosis inducer
Dahong Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Novel anticancer oridonin derivatives possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Design, synthesis, biological evaluation and nitric oxide release studies
Shengtao Xu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Molecular mechanisms for tumour resistance to chemotherapy
Shu-Ting Pan et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2016)
Discovery and development of natural product oridonin-inspired anticancer agents
Ye Ding et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Oridonin Inhibits Cell Proliferation and Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Cai-hong Shang et al.
INFLAMMATION (2016)
Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: Involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway
Shijie Cao et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2016)
Oridonin inhibits gefitinib-resistant lung cancer cells by suppressing EGFR/ERK/MMP-12 and CIP2A/Akt signaling pathways
Xiangling Xiao et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2016)
Oridonin derivative ameliorates experimental colitis by inhibiting activated T-cells and translocation of nuclear factor-kappa B
Qian Qian Liu et al.
JOURNAL OF DIGESTIVE DISEASES (2016)
Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma
Kai Qing et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2016)
Protective effects of oridonin on the sepsis in mice
Yan-Jun Zhao et al.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2016)
Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression
Shihong Ma et al.
MOLECULAR MEDICINE REPORTS (2016)
Investigation of the anti-asthmatic activity of Oridonin on a mouse model of asthma
Jing Wang et al.
MOLECULAR MEDICINE REPORTS (2016)
Antitumor and Antibacterial Derivatives of Oridonin: A Main Composition of Dong-Ling-Cao
Dahong Li et al.
MOLECULES (2016)
NO-Releasing Enmein-Type Diterpenoid Derivatives with Selective Antiproliferative Activity and Effects on Apoptosis-Related Proteins
Dahong Li et al.
MOLECULES (2016)
Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues
Wei Chen et al.
ONCOTARGET (2016)
Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway
Sai-Qi Wang et al.
ONCOTARGET (2016)
Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species
Yong-Cheng Ma et al.
ONCOTARGET (2016)
Oridonin stabilizes retinoic acid receptor alpha through ROS-activated NF- κB signaling
Yang Cao et al.
BMC CANCER (2015)
Oridonin's therapeutic effect: Suppressing Th1/Th17 simultaneously in a mouse model of Crohn's disease
Shubei Wang et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015)
Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis
Fredrick J. Bohanon et al.
JOURNAL OF SURGICAL RESEARCH (2015)
Synergistic anticancer effects of combined γ-tocotrienol and oridonin treatment is associated with the induction of autophagy
Roshan V. Tiwari et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2015)
Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells
Fredrick J. Bohanon et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2015)
Absence of RIPK3 predicts necroptosis resistance in malignant melanoma
P. Geserick et al.
CELL DEATH & DISEASE (2015)
Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells
Yue Li et al.
MEDICAL ONCOLOGY (2015)
Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives
Shengtao Xu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Multi-drug resistance in cancer chemotherapeutics: Mechanisms and lab approaches
Qiong Wu et al.
CANCER LETTERS (2014)
Inhibition of miR-17 and miR-20a by Oridonin Triggers Apoptosis and Reverses Chemoresistance by Derepressing BIM-S
Hengyou Weng et al.
CANCER RESEARCH (2014)
ROS Function in Redox Signaling and Oxidative Stress
Michael Schieber et al.
CURRENT BIOLOGY (2014)
gamma-Tocotrienol-induced autophagy in malignant mammary cancer cells
Roshan V. Tiwari et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2014)
Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis
Fredrick J. Bohanon et al.
JOURNAL OF SURGICAL RESEARCH (2014)
Enhancement of the effects of gemcitabine against pancreatic cancer by oridonin via the mitochondrial caspase-dependent signaling pathway
Dian-Lei Liu et al.
MOLECULAR MEDICINE REPORTS (2014)
Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells
Liang-Mou Kuo et al.
MOLECULES (2014)
ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids
Chunyong Ding et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2014)
Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation
Dahong Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells
Dahong Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Oridonin ameliorates lupus-like symptoms of MRLlpr/lpr mice by inhibition of B-cell activating factor (BAFF)
Lin Zhou et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2013)
Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis
Zhi-Yuan Zhang et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2013)
Novel Nitrogen-Enriched Oridonin Analogues with Thiazole-Fused A-Ring: Protecting Group-Free Synthesis, Enhanced Anticancer Profile, and Improved Aqueous Solubility
Chunyong Ding et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Oridonin Ring A-Based Diverse Constructions of Enone Functionality: Identification of Novel Dienone Analogues Effective for Highly Aggressive Breast Cancer by Inducing Apoptosis
Chunyong Ding et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Overcoming Synthetic Challenges of Oridonin A-Ring Structural Diversification: Regio- and Stereoselective Installation of Azides and 1,2,3-Triazoles at the C-1, C-2, or C-3 Position
Chunyong Ding et al.
ORGANIC LETTERS (2013)
Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1
Rong Zeng et al.
ACTA PHARMACOLOGICA SINICA (2012)
Oridonin in combination with imatinib exerts synergetic anti-leukemia effects in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway
Yong Guo et al.
CANCER BIOLOGY & THERAPY (2012)
The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: Synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents
Lei Wang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway
He-Qi Bu et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2012)
Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis
Hui-Lin Huang et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Synthesis and Biological Evaluation of Novel Furozan-Based Nitric Oxide-Releasing Derivatives of Oridonin as Potential Anti-Tumor Agents
Dahong Li et al.
MOLECULES (2012)
Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells
Sophie Chen et al.
CELL BIOLOGY AND TOXICOLOGY (2011)
NMR spectra and structures of oridonin derivatives complexes with β-cyclodextrin
Wei Liu et al.
MAGNETIC RESONANCE IN CHEMISTRY (2011)
Anti-cancer natural products isolated from chinese medicinal herbs
Wen Tan et al.
CHINESE MEDICINE (2011)
Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance
Zhiwei Wang et al.
DRUG RESISTANCE UPDATES (2010)
Arsenic trioxide induces the apoptosis in vascular smooth muscle cells via increasing intracellular calcium and ROS formation
Jing-Xiu Li et al.
MOLECULAR BIOLOGY REPORTS (2010)
Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia
Yan Xu et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2009)
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Dunyaporn Trachootham et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates
Jinyi Xu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response
Yu Du et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2008)
Oridonin promotes CD4+/CD25+Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes
A. -P. Hu et al.
INFLAMMATION RESEARCH (2008)
Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways
Jian Huang et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2008)
Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells
Qiao Cui et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2007)
Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma
Wen Xu et al.
ACTA PHARMACOLOGICA SINICA (2006)
Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cells
Jun-Feng Zhang et al.
HEPATOLOGY RESEARCH (2006)
The stem cell factor receptor/c-Kit as a drug target in cancer
J Lennartsson et al.
CURRENT CANCER DRUG TARGETS (2006)
Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis
J Huang et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2005)
Oridonin enhances phagoeytosis of UV-irradiated apoptotic U937 cells
YQ Liu et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2005)
Oridonin induced A375-S2 cell apoptosis via Bax-regulated caspase pathway activation, dependent on the cytochrome C/CASPASE-9 apoptosome
CL Zhang et al.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2004)
Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action
JJ Liu et al.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2004)
Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activation
CL Zhang et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2004)
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
NP Shah et al.
CANCER CELL (2002)
Death and anti-death: Tumour resistance to apoptosis
FH Igney et al.
NATURE REVIEWS CANCER (2002)
Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells
T Efferth et al.
BLOOD CELLS MOLECULES AND DISEASES (2002)