Journal
EXPERIMENTAL EYE RESEARCH
Volume 156, Issue -, Pages 41-49Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2016.03.016
Keywords
Cytoskeleton; Tubulin; Actin; Cell shape; Differentiation
Categories
Funding
- National Eye Institute [EY012221, EY015279]
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Lens fiber cells are highly elongated cells with complex membrane morphologies that are critical for the transparency of the ocular lens. Investigations into the molecular mechanisms underlying lens fiber cell elongation were first reported in the 1960s, however, our understanding of the process is still poor nearly 50 years later. This review summarizes what is currently hypothesized about the regulation of lens fiber cell elongation along with the available experimental evidence, and how this information relates to what is known about the regulation of cell shape/elongation in other cell types, particularly neurons. (C) 2016 Elsevier Ltd. All rights reserved.
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