4.7 Article

What's Sex Got to Do With It? Understanding Potential Confounding and Exposure Misclassification in Mechanistic Sexually Transmitted Infection Research

Journal

JOURNAL OF INFECTIOUS DISEASES
Volume 224, Issue 1, Pages 137-140

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa705

Keywords

cytokine; HIV; prostate-specific antigen; sexually transmitted infection

Funding

  1. University of North Carolina at Chapel Hill Center for AIDS Research [P30 AI050410]

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In a prospective study of 13 heterosexual couples, it was found that all vaginal immune markers were detectable in semen, and concentrations of these markers varied based on the recency of sexual activity.
We conducted a prospective study of 13 heterosexual couples to understand the impact of recent condomless vaginal sex on vaginal immune marker measurement and potential exposure misclassification due to the presence of semen. All immune markers were detectable in semen and concentrations of vaginal immune markers varied by sex recency.

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