Journal
EXPERIMENTAL DERMATOLOGY
Volume 26, Issue 11, Pages 999-1003Publisher
WILEY
DOI: 10.1111/exd.13329
Keywords
acidification; barrier function; pH; stratum corneum
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In this article, I review the multiple endogenous mechanisms that contribute to the highly acidic pH of normal stratum corneum (SC). Then, I describe how each mechanism potentially impacts specific defensive functions of the SC. Finally, I review the rapidly expanding, clinical implications and potential therapeutic applications of SC acidification.
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