Risk factors and clinical course of children with cystic fibrosis colonized with Staphylococcus aureus

Background: The Literature is Limited on staphylococcal infection in children with cystic fibrosis (CF) from tropical countries. We aimed to study the risk factors and clinical course of children with CF infected with Staphylococcus aureus. Methods: In this chart review we compared demographic, clinical and spirometry characteristics in CF children with S. aureus alone (group A), both S. aureus and Pseudomonas aeruginosa (group B) and P. aeruginosa alone (group C) colonization. Results: We included 79 cases (group A, 22; group B, 19; group C, 38). There was no difference in age of onset of symptoms, age of diagnosis, age of first isolation and spirometry parameters before colonization between the groups. The median duration of follow-up was shorter in group A. After colonization, children in group A and group B had significantly Lower mean Shwachman and Kulczycki (SK) scores (44.7 +/- 5.4 and 40.8 +/- 5.8, respectively) compared with group C (49.9 +/- 6.8). Pulmonary exacerbations and hospitalizations were significantly greater in the combined group. After colonization, group A had a significant deterioration in SK score and forced vital capacity (FVC). Conclusions: S. aureus colonization, especially in combination with P. aeruginosa, in children with CF was associated with worsening of FVC and clinical severity score and increased pulmonary exacerbations.

Automated summary

The study found that Staphylococcus aureus colonization, especially when combined with Pseudomonas aeruginosa, in children with cystic fibrosis was associated with worsening of forced vital capacity (FVC) and clinical severity score, as well as increased pulmonary exacerbations.