Journal
EXPERIMENTAL CELL RESEARCH
Volume 352, Issue 2, Pages 420-426Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2017.02.038
Keywords
Modulation; Hepatic stellate cells; Reversibility; Hepatic fibrosis; Mechanism
Categories
Funding
- National Natural Science Foundation of China [81360595, 81160433]
- Guangxi Natural Science Foundation [2013GXNSFBA019188]
- Guangxi Provincial Medicine and Health Industry
- Guangxi Bagui scholars and Guangxi distinguished experts
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Hepatic fibrosis (HF) is the pathological component of a variety of chronic liver diseases. Hepatic stellate cells (HSC) are the main collagen-producing cells in the liver and their activation promotes HF. If HSC activation and proliferation can be inhibited, HF occurrence and development can theoretically be reduced and even reversed. Over the past ten years, a number of studies have addressed this process, and here we present a review of HSC modulation and HF reversal.
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