Journal
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
Volume 10, Issue 5, Pages 669-673Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jpids/piaa161
Keywords
antibodies; COVID-19; multisystem inflammatory syndrome in children (MIS-C); pediatric; SARS-COV-2
Categories
Funding
- University of Pennsylvania
- National Institutes of Health Training in Virology T32 Program [T32-AI-007324]
- Institute for Translational Medicine and Therapeutics of the Perelman School of Medicine at the University of Pennsylvania
- National Institutes of Health Emerging Infectious Diseases T32 Program [T32-AI055400]
- National Institutes of Health [R21AI129531, R21AI142638]
- peer-reviewed Medical Research Program [PR182551]
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Pediatric patients with MIS-C have higher SARS-CoV-2 spike IgG titers, possibly indicating a longer time since infection onset.
Severe acute respiratory syndrome-coronavirus-2 (SARSCoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike immunoglobulin G (IgG) titers compared with those with severe coronavirus disease 2019, likely reflecting a longer time since the onset of infection in MIS-C patients.
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