Journal
EXPERIMENTAL CELL RESEARCH
Volume 360, Issue 1, Pages 24-26Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2017.03.049
Keywords
Glucocorticoid; Nuclear receptor; mTOR; KLF15; REDD1; FGF21; Alanine; Amino acid
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Funding
- Ministry of Health, Labor, and Welfare
- IMSUT Joint Research Project
- Grants-in-Aid for Scientific Research [17K09876, 16K09230, 15KK0332, 16H05330] Funding Source: KAKEN
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Glucocorticoids (GCs) affect nearly every organ and tissue in the body, regulating diverse physiologic processes including energy homeostasis. The metabolic mission of GCs is to supply enough glucose into the circulation to fuel the brain and ensure survival of the organism under conditions of acute stress or starvation. Recent studies have revealed that GCs, via orchestration between multiple organs, physiologically elicit fine tuning of systemic energy metabolism.
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