Journal
EXPERIMENTAL CELL RESEARCH
Volume 358, Issue 1, Pages 31-38Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2017.06.003
Keywords
Endothelial cells; Adherens junctions; Tight junctions; Rho; GTPases Rap GTPases; Actin cytoskeleton; Cell signaling
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Funding
- Cancer Research UK [C6620/A15961]
- Cancer Research UK [15961] Funding Source: researchfish
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Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and leukocyte transendothelial migration, focusing particularly on signals mediated by small GTPases that regulate cell adhesion and the actin cytoskeleton. Rho and Rap GTPase signaling is important for both processes, but they differ in that signals are activated locally under leukocytes, whereas endothelial permeability is a wider event that affects the whole cell. Some molecules play a unique role in one of the two processes, and could therefore be targeted to selectively alter either endothelial permeability or leukocyte transendothelial migration.
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