Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 242, Issue 17, Pages 1690-1700Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370217697386
Keywords
Microphysiologic systems; microfluidic systems; organ on a chip; female reproductive tract; reproductive biology; personalized medicine
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Funding
- National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, Maryland [UH3 TR001207]
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Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a tissue-tissue interface or physical forces like fluid sheer stress. The female reproductive system is a series of interconnected organs that are necessary to produce eggs, support embryo development and female health, and impact the functioning of non-reproductive tissues throughout the body. Despite its importance, the human reproductive tract has received less attention than other organ systems, such as the liver and kidney, in terms of modeling with MPS. In this review, we discuss current gaps in the field and areas for technological advancement through the application of MPS. We explore current MPS research in female reproductive biology, including fertilization, pregnancy, and female reproductive tract diseases, with a focus on their clinical applications.
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