Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 242, Issue 17, Pages 1701-1713Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370217694101
Keywords
Pumpless; serum free; organ on a chip; organ-organ interactions; functional measurement; microphysiological systems
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Funding
- National Institutes of Health [R44 TR001326-0A1]
- National Center for Advancing Translational Sciences at the National Institutes of Health [UH2TR000516]
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Integrated multi-organ microphysiological systems are an evolving tool for preclinical evaluation of the potential toxicity and efficacy of drug candidates. Such systems, also known as Body-on-a-Chip devices, have a great potential to increase the successful conversion of drug candidates entering clinical trials into approved drugs. Systems, to be attractive for commercial adoption, need to be inexpensive, easy to operate, and give reproducible results. Further, the ability to measure functional responses, such as electrical activity, force generation, and barrier integrity of organ surrogates, enhances the ability to monitor response to drugs. The ability to operate a system for significant periods of time (up to 28d) will provide potential to estimate chronic as well as acute responses of the human body. Here we review progress towards a self-contained low-cost microphysiological system with functional measurements of physiological responses.
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