Encapsulation and controlled release of an antimalarial drug using surface functionalized mesoporous silica nanocarriers

Herein, we report the encapsulation and release of antimalarial drug quinine (QN) using three nanocarriers, including MCM-41 (1), and its 3-aminopropyl silane (aMCM-41 (2)) and 3-phenylpropyl silane (pMCM-41 (3)) surface functionalized derivatives. The pH and thermal optimization effects on QN adsorption and release from 1, 2 and 3 were investigated.

Automated summary

In this study, encapsulation and release of antimalarial drug quinine using three nanocarriers were investigated, with pH and thermal optimization effects on drug adsorption and release from the nanocarriers explored.