Journal
ANNALS OF MEDICINE AND SURGERY
Volume 65, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.amsu.2021.102303
Keywords
PAI-1; Oral squamous cell carcinoma; Lymph node; Prognostic marker
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq/133653/20129]
- Fundacao de Amparo a Pesquisa do Estado do Espirito Santo [FAPES/54653363/11]
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The study revealed a significant association between positive PAI-1 expression in mononuclear inflammatory cell infiltrate and lymph node status as well as cytoplasmic expression of VEGFA in OSCC. Multivariate analysis demonstrated weak PAI-1 expression as an independent marker for lymph node metastases, with approximately 8-fold increased risk compared to strong expression.
Introduction: Immune cells contribute with mediators in the protein expression profile of the tumor microenvironment. Levels of plasminogen activator inhibitor-1 (PAI-1) are elevated in non-malignant inflammatory conditions; however, the association between PAI-1 expression and inflammation remains uncertain in oral squamous cell carcinoma (OSCC). This study aimed to investigate PAI-1 expression in mononuclear inflammatory cell infiltrate in OSCC and its role as a prognostic marker. Methods: Samples were collected from patients with OSCC, treated surgically, and followed for 24 months after the procedure. Thirty-nine tumoral tissue were analyzed using immunohistochemistry. Correlation between protein expression, clinicopathological parameters, and the prognosis was investigated. Results: Positive PAI-1 expression in mononuclear inflammatory cell infiltrate was significantly associated with lymph node status (p = 0.009) and with the cytoplasmic expression of vascular endothelial growth factor A (VEGFA) (p = 0.028). Multivariate analysis revealed weak PAI-1 expression as an independent marker for lymph node metastases, with approximately 8-fold increased risk compared to strong expression (OR = 8.60; CI = 1.54-48.08; p = 0.014). Conclusion: Our results suggest that the strong PAI-1 expression in intratumoral inflammatory infiltrate is an indicator of a better prognosis for patients diagnosed with oral squamous cell carcinoma.
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