Journal
SEMINARS IN NEPHROLOGY
Volume 41, Issue 2, Pages 133-143Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semnephrol.2021.03.008
Keywords
Thyroid function; thyrotropin; hypothyroidism; hyperthyroidism; chronic kidney disease; dialysis
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Funding
- Uehara Memorial Foundation for Overseas postdoctoral fellowships
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases [R03DK114642, R01DK122767, R01-DK124138]
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Hypothyroidism is common in CKD patients and has a bidirectional relationship with kidney disease, but there are gaps in knowledge regarding clinical management. Future research is needed to establish appropriate screening, diagnosis, and treatment approaches.
Hypothyroidism is a highly prevalent endocrine complication in chronic kidney disease (CKD) patients. A large body of evidence has shown that there is a bidirectional relationship between thyroid dysfunction and kidney disease, yet there are many remaining gaps in knowledge in regards to the clinical management of CKD patients with hypothyroidism, including those receiving hemodialysis and peritoneal dialysis. Given that hypothyroidism has been associated with many deleterious outcomes including a higher risk of (1) mortality, (2) cardiovascular disease, (3) impaired health-related quality of life, and (4) altered body composition in both non-CKD and CKD patients, future research is needed to establish the appropriate screening, diagnosis, and treatment approaches in these populations. (C) 2021 Elsevier Inc. All rights reserved.
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