Related references
Note: Only part of the references are listed.Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks
Helen Zhu et al.
MOLECULAR CELL (2020)
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
Esther Rheinbay et al.
NATURE (2020)
Pan-cancer analysis of whole genomes
Peter J. Campbell et al.
NATURE (2020)
Global cancer genomics project comes to fruition
Marcin Cieslik et al.
NATURE (2020)
Combined burden and functional impact tests for cancer driver discovery using DriverPower
Shimin Shuai et al.
NATURE COMMUNICATIONS (2020)
Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer
Stanley Zhou et al.
NATURE COMMUNICATIONS (2020)
Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer
Rosario Corona et al.
NATURE COMMUNICATIONS (2020)
Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies
Kailong Li et al.
CANCER DISCOVERY (2020)
MutEnricher: a flexible toolset for somatic mutation enrichment analysis of tumor whole genomes
Anthony R. Soltis et al.
BMC BIOINFORMATICS (2020)
MutSpot: detection of non-coding mutation hotspots in cancer genomes
Yu Amanda Guo et al.
NPJ GENOMIC MEDICINE (2020)
Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X
Yu Liu et al.
NATURE GENETICS (2020)
Illuminating the noncoding genome in cancer
Xiaoyang Zhang et al.
NATURE CANCER (2020)
Pan-cancer analysis of somatic mutations in miRNA genes
Martyna O. Urbanek-Trzeciak et al.
EBIOMEDICINE (2020)
ncdDetect2: improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation
Malene Juul et al.
BIOINFORMATICS (2019)
Local Determinants of the Mutational Landscape of the Human Genome
Abel Gonzalez-Perez et al.
CELL (2019)
Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
Song Wu et al.
NATURE COMMUNICATIONS (2019)
New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis
Yutong Sun et al.
CANCERS (2019)
Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes
Eric Minwei Liu et al.
CELL SYSTEMS (2019)
Scales and mechanisms of somatic mutation rate variation across the human genome
Fran Supek et al.
DNA REPAIR (2019)
Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features
Remi Buisson et al.
SCIENCE (2019)
A compendium of promoter-centered long-range chromatin interactions in the human genome
Inkyung Jung et al.
NATURE GENETICS (2019)
Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma
Hiromichi Suzuki et al.
NATURE (2019)
The U1 spliceosomal RNA is recurrently mutated in multiple cancers
Shimin Shuai et al.
NATURE (2019)
Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution
Martin Kircher et al.
NATURE COMMUNICATIONS (2019)
Involvement of the long noncoding RNA NEAT1 in carcinogenesis
Christiane Klec et al.
MOLECULAR ONCOLOGY (2019)
COSMIC: the Catalogue Of Somatic Mutations In Cancer
John G. Tate et al.
NUCLEIC ACIDS RESEARCH (2019)
The Untranslated Regions of mRNAs in Cancer
Samantha L. Schuster et al.
TRENDS IN CANCER (2019)
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
David C. Wedge et al.
NATURE GENETICS (2018)
Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
Yu Amanda Guo et al.
NATURE COMMUNICATIONS (2018)
ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
Peng Mao et al.
NATURE COMMUNICATIONS (2018)
Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival
Henrik Hornshoj et al.
NPJ GENOMIC MEDICINE (2018)
Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
Sarah E. Arthur et al.
NATURE COMMUNICATIONS (2018)
Explaining cancer type specific mutations with transcriptomic and epigenomic features in normal tissues
Khong-Loon Tiong et al.
SCIENTIFIC REPORTS (2018)
SMuRF: a novel tool to identify regulatory elements enriched for somatic point mutations
Paul Guilhamon et al.
BMC BIOINFORMATICS (2018)
Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers
Kerryn Elliott et al.
PLOS GENETICS (2018)
MOAT: efficient detection of highly mutated regions with the Mutations Overburdening Annotations Tool
Lucas Lochovsky et al.
BIOINFORMATICS (2018)
Multiplexed Engineering and Analysis of Combinatorial Enhancer Activity in Single Cells
Shiqi Xie et al.
MOLECULAR CELL (2017)
Recurrent and functional regulatory mutations in breast cancer
Esther Rheinbay et al.
NATURE (2017)
Reduced mutation rate in exons due to differential mismatch repair
Joan Frigola et al.
NATURE GENETICS (2017)
A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells
Yarui Diao et al.
NATURE METHODS (2017)
Discovery of Cancer Driver Long Noncoding RNAs across 1112 Tumour Genomes: New Candidates and Distinguishing Features
Andres Lanzos et al.
Scientific Reports (2017)
Understanding Tissue-Specific Gene Regulation
Abhijeet Rajendra Sonawane et al.
CELL REPORTS (2017)
Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational signature
Nils Johan Fredriksson et al.
PLOS GENETICS (2017)
Whole-genome analysis of papillary kidney cancer finds significant noncoding alterations
Shantao Li et al.
PLOS GENETICS (2017)
Universal Patterns of Selection in Cancer and Somatic Tissues
Inigo Martincorena et al.
CELL (2017)
Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations
Shaoyan Hu et al.
BLOOD (2017)
Insertions and Deletions Target Lineage-Defining Genes in Human Cancers
Marcin Imielinski et al.
CELL (2017)
Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations
Carlos L. Araya et al.
NATURE GENETICS (2016)
A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening
Yarui Diao et al.
GENOME RESEARCH (2016)
A Significant Regulatory Mutation Burden at a High-Affinity Position of the CTCF Motif in Gastrointestinal Cancers
Husen M. Umer et al.
HUMAN MUTATION (2016)
TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data
Liacine Bouaoun et al.
HUMAN MUTATION (2016)
Understanding TERT Promoter Mutations: A Common Path to Immortality
Robert J. A. Bell et al.
MOLECULAR CANCER RESEARCH (2016)
Nucleotide excision repair is impaired by binding of transcription factors to DNA
Radhakrishnan Sabarinathan et al.
NATURE (2016)
Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes
Dilmi Perera et al.
NATURE (2016)
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Serena Nik-Zainal et al.
NATURE (2016)
High-throughput mapping of regulatory DNA
Nisha Rajagopal et al.
NATURE BIOTECHNOLOGY (2016)
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
Gozde Korkmaz et al.
NATURE BIOTECHNOLOGY (2016)
Chromatin structure-based prediction of recurrent noncoding mutations in cancer
Kwoneel Kim et al.
NATURE GENETICS (2016)
Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer
Swneke D. Bailey et al.
NATURE GENETICS (2016)
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
Akihiro Fujimoto et al.
NATURE GENETICS (2016)
Role of non-coding sequence variants in cancer
Ekta Khurana et al.
NATURE REVIEWS GENETICS (2016)
Activation of proto-oncogenes by disruption of chromosome neighborhoods
Denes Hnisz et al.
SCIENCE (2016)
High-resolution interrogation of functional elements in the noncoding genome
Neville E. Sanjana et al.
SCIENCE (2016)
Systematic mapping of functional enhancer-promoter connections with CRISPR interference
Charles P. Fulco et al.
SCIENCE (2016)
Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies
Andrew J. Colebatch et al.
ONCOTARGET (2016)
Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif
Rebecca C. Poulos et al.
CELL REPORTS (2016)
Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution
Jimmy Van den Eynden et al.
PLOS GENETICS (2016)
Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types
Vera B. Kaiser et al.
PLOS GENETICS (2016)
OncodriveFML: a general framework to identify coding and non-coding regions with cancer driver mutations
Loris Mularoni et al.
GENOME BIOLOGY (2016)
Differential DNA mismatch repair underlies mutation rate variation across the human genome
Fran Supek et al.
NATURE (2015)
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente et al.
NATURE (2015)
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Matthew C. Canver et al.
NATURE (2015)
Cell-of-origin chromatin organization shapes the mutational landscape of cancer
Paz Polak et al.
NATURE (2015)
CTCF/cohesin-binding sites are frequently mutated in cancer
Riku Katainen et al.
NATURE GENETICS (2015)
LARVA: an integrative framework for large-scale analysis of recurrent variants in noncoding annotations
Lucas Lochovsky et al.
NUCLEIC ACIDS RESEARCH (2015)
Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants
Aziz Belkadi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
Robert J. A. Bell et al.
SCIENCE (2015)
Frequent DPH3 promoter mutations in skin cancers
Evgeniya Denisova et al.
ONCOTARGET (2015)
Mechanisms of mutational robustness in transcriptional regulation
Joshua L. Payne et al.
FRONTIERS IN GENETICS (2015)
MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival
B-S Li et al.
ONCOGENE (2015)
The mini-driver model of polygenic cancer evolution
Francesc Castro-Giner et al.
NATURE REVIEWS CANCER (2015)
Discovery and saturation analysis of cancer genes across 21 tumour types
Michael S. Lawrence et al.
NATURE (2014)
Genome-wide analysis of noncoding regulatory mutations in cancer
Nils Weinhold et al.
NATURE GENETICS (2014)
Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types
Nils J. Fredriksson et al.
NATURE GENETICS (2014)
An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element
Marc R. Mansour et al.
SCIENCE (2014)
Transcription Restores DNA Repair to Heterochromatin, Determining Regional Mutation Rates in Cancer Genomes
Christina L. Zheng et al.
CELL REPORTS (2014)
Lessons from the Cancer Genome
Levi A. Garraway et al.
CELL (2013)
Mutational heterogeneity in cancer and the search for new cancer-associated genes
Michael S. Lawrence et al.
NATURE (2013)
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov et al.
NATURE (2013)
Emerging landscape of oncogenic signatures across human cancers
Giovanni Ciriello et al.
NATURE GENETICS (2013)
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Patrick J. Killela et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Impact of deleterious passenger mutations on cancer progression
Christopher D. McFarland et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
TERT Promoter Mutations in Familial and Sporadic Melanoma
Susanne Horn et al.
SCIENCE (2013)
Highly Recurrent TERT Promoter Mutations in Human Melanoma
Franklin W. Huang et al.
SCIENCE (2013)
Frequency of TERT promoter mutations in human cancers
Joao Vinagre et al.
NATURE COMMUNICATIONS (2013)
Length and GC-biases during sequencing library amplification: A comparison of various polymerase-buffer systems with ancient and modern DNA sequencing libraries
Jesse Dabney et al.
BIOTECHNIQUES (2012)
Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions
Steven A. Roberts et al.
MOLECULAR CELL (2012)
Chromatin organization is a major influence on regional mutation rates in human cancer cells
Benjamin Schuster-Boeckler et al.
NATURE (2012)
The Mechanisms of UV Mutagenesis
Hironobu Ikehata et al.
JOURNAL OF RADIATION RESEARCH (2011)
Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions
Weixin Wang et al.
SCIENTIFIC REPORTS (2011)
Retroviral restriction by APOBEC proteins
RS Harris et al.
NATURE REVIEWS IMMUNOLOGY (2004)
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
L Pasqualucci et al.
NATURE (2001)