Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 45, Issue 2, Pages 80-86Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000106
Keywords
sitting; physical activity; vascular function; shear stress; cardiovascular risk factors
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Funding
- Biotechnology and Biological Sciences Research Council [1539216] Funding Source: researchfish
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Sedentary behavior has a strong association with cardiovascular disease (CVD) risk, which may be independent of physical activity. To date, the mechanism(s) that mediate this relationship are poorly understood. We hypothesize that sedentary behavior modifies key hemodynamic, inflammatory, and metabolic processes resulting in impaired arterial health. Subsequently, these vascular impairments directly and indirectly contribute to the development of CVD.
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