4.5 Review

Arterial Ventricular Uncoupling With Age and Disease and Recoupling With Exercise

Journal

EXERCISE AND SPORT SCIENCES REVIEWS
Volume 45, Issue 2, Pages 70-79

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000100

Keywords

arterial ventricular coupling; aging; cardiovascular disease; exercise training

Funding

  1. Center for Cardiovascular and Respiratory Sciences and the Clinical and Translational Sciences Institute at the West Virginia University Health Sciences Center
  2. American Heart Association [11CRP7370056]
  3. National Institutes of Health [5P20GM109098]
  4. National Institute of General Medical Sciences of the National Institutes of Health [U54GM104942]

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The deterioration in arterial and cardiac function with aging impairs arterial ventricular coupling, an important determinant of cardiovascular performance. However, exercise training improves arterial ventricular coupling especially during exercise. This review examines the concept of arterial-ventricular coupling and how age and disease uncouples, but exercise training recouples, the heart and arterial system.

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