Chemical technologies for precise protein bioconjugation interfacing biology and medicine

Proteins provide an excellent means to monitor and regulate biological processes. Hence, a precise chemical toolbox for their modification becomes indispensable. In this perspective, this feature article outlines our efforts to establish the core principles of chemoselectivity, site-selectivity, site-specificity, site-modularity, residue-modularity, and protein-specificity. With the knowledge to systematically regulate these parameters, the field has access to technological platforms that can address multiple challenges at the interface of chemistry, biology, and medicine.

Automated summary

Proteins play a crucial role in monitoring and regulating biological processes, making precise modification tools essential. The establishment of core principles such as chemoselectivity, site-selectivity, and protein-specificity is key in addressing challenges at the intersection of chemistry, biology, and medicine. These principles provide a technological platform for systematically regulating parameters and overcoming various challenges in the field.