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Chemical technologies for precise protein bioconjugation interfacing biology and medicine

Journal

CHEMICAL COMMUNICATIONS
Volume 57, Issue 58, Pages 7083-7095

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc02268g

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Funding

  1. SERB, DST, DBT
  2. IISER Bhopal
  3. UGC
  4. Swarnajayanti Fellowship [DST/SJF/CSA-01/2018-19, SB/SJF/2019-20/01]
  5. PMRF

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Proteins play a crucial role in monitoring and regulating biological processes, making precise modification tools essential. The establishment of core principles such as chemoselectivity, site-selectivity, and protein-specificity is key in addressing challenges at the intersection of chemistry, biology, and medicine. These principles provide a technological platform for systematically regulating parameters and overcoming various challenges in the field.
Proteins provide an excellent means to monitor and regulate biological processes. Hence, a precise chemical toolbox for their modification becomes indispensable. In this perspective, this feature article outlines our efforts to establish the core principles of chemoselectivity, site-selectivity, site-specificity, site-modularity, residue-modularity, and protein-specificity. With the knowledge to systematically regulate these parameters, the field has access to technological platforms that can address multiple challenges at the interface of chemistry, biology, and medicine.

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