4.7 Article

Iron-catalyzed alkylation of carbazole derivatives via hydroarylation of styrenes

Journal

CHEMICAL COMMUNICATIONS
Volume 57, Issue 58, Pages 7148-7151

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc02449c

Keywords

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Funding

  1. Zhejiang Provincial Natural Science Foundation of China [LY19B020003, LY20B020004]
  2. Ningbo Natural Science Foundation [202003N4009]

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This study demonstrates the first direct and selective 3,6-di-alkylation of carbazoles through iron-catalyzed hydroarylation of styrenes. The method is simple, general, and efficient, delivering a wide range of di-benzyl-carbazoles in up to 96% yield at room temperature without the need for a noble-metal catalyst, directing group, or additives.
The first direct and selective 3,6-di-alkylation of carbazoles via iron-catalyzed hydroarylation of styrenes is demonstrated. This simple, general and efficient method could deliver a wide range of di-benzyl-carbazoles with high chemo- and regio-selectivity at room temperature in up to 96% yield with no need for a noble-metal catalyst, directing group or additives.

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