Journal
CHEMICAL SCIENCE
Volume 12, Issue 30, Pages 10191-10196Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sc02360h
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Funding
- Hellenic Foundation for Research and Innovation (HFRI) - H. F. R. I. Research Projects [655]
- State Scholarships Foundation (IKY) - action of the Operational Programme Human Resources Development, Education and Lifelong Learning [MIS 5033021]
- European Social Fund (ESF)
- Greek National Resources
- COST Action C-H Activation in Organic Synthesis [CA15106]
- Swiss National Science Foundation
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The organocatalytic epoxidation of unactivated alkenes using aqueous hydrogen peroxide provides essential products and intermediates in a sustainable manner. A specific atropisomeric two-axis aldehyde was identified for high-yielding epoxidations of cyclic and acyclic alkenes, resulting in high catalytic efficiencies due to the proximity of the aldehyde and backbone residues. Mechanistic studies suggest a non-radical alkene oxidation by an aldehyde-derived dioxirane intermediate generated from hydrogen peroxide through the Payne and Criegee intermediates.
The organocatalytic epoxidation of unactivated alkenes using aqueous hydrogen peroxide provides various indispensable products and intermediates in a sustainable manner. While formyl functionalities typically undergo irreversible oxidations when activating an oxidant, an atropisomeric two-axis aldehyde capable of catalytic turnover was identified for high-yielding epoxidations of cyclic and acyclic alkenes. The relative configuration of the stereogenic axes of the catalyst and the resulting proximity of the aldehyde and backbone residues resulted in high catalytic efficiencies. Mechanistic studies support a non-radical alkene oxidation by an aldehyde-derived dioxirane intermediate generated from hydrogen peroxide through the Payne and Criegee intermediates.
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