Journal
AGING-US
Volume 13, Issue 11, Pages 15384-15399Publisher
IMPACT JOURNALS LLC
Keywords
salivary adenoid cystic carcinoma (SACC); CXCR5; perineural invasion (PNI); microRNAs (miRNAs); Schwann cells
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Funding
- National Natural Science Foundation of China [81972542, 82073000]
- Science and Technology of Sichuan Province [2020YFS0171, 2020JDRC0018]
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Our study confirmed the role of CXCR5 in SACC, facilitating PNI by downregulating miR-187 to disinhibit S100A4 expression.
CXCR5 played critical roles in tumorigenesis and metastasis. Nevertheless, little was known about the involvement of CXCR5 in perineural invasion (PNI) of salivary adenoid cystic carcinoma (SACC). Here, we confirmed upregulation of CXCR5 in SACC specimens and cells and identified that CXCR5 exhibited a significant positive correlation with PNI. Functionally, knockdown of CXCR5 suppressed SACC cells migration, invasion and PNI ability, whereas CXCR5 overexpression displayed the opposite effects. Moreover, CXCR5 downregulated microRNA (miR)-187, which could competitively sponge S100A4. The PNI-inhibitory effect of CXCR5 knockdown or miR-187 overexpression could be reversed by elevated expression of S100A4. Conjointly, our data revealed that CXCR5 facilitated PNI through downregulating miR-187 to disinhibit S100A4 expression in SACC.
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