Journal
CURRENT ONCOLOGY
Volume 28, Issue 3, Pages 2115-2122Publisher
MDPI
DOI: 10.3390/curroncol28030196
Keywords
targeted osmotic lysis; advanced-stage cervical cancer; sodium channels; sodium pumps
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Funding
- Dorothy Dorsett Brown Foundation
- Oleander Medical Technologies
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TOL technology, through the stimulation of VGSCs and blocking of sodium pumps, has shown to be an effective and safe treatment for aggressive advanced carcinomas, extending patients' lives without compromising quality of life. This treatment may have broad applications for advanced-stage carcinomas.
Upregulation of voltage-gated sodium channels (VGSCs) and Na+/K+-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas.
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