3.8 Article

Absolute Configuration of In Situ Crystallized (+)-γ-Decalactone

Journal

CHEMISTRY-SWITZERLAND
Volume 3, Issue 2, Pages 578-584

Publisher

MDPI
DOI: 10.3390/chemistry3020040

Keywords

gamma-(+)-decalactone; absolute configuration; in situ cryo-crystallization; flavoring agent; lactone; hydrogen bonding; crystal structure; X-ray crystallography

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X-ray crystallography allows for the determination of the absolute configuration of small bioactive organic molecules. In this study, the absolute configuration of the flavoring agent (+)-gamma-decalactone was determined through single crystal analysis. The molecule consists of a linear aliphatic non-polar backbone and a polar lactone head, with observations of layers alternating along the c-axis in the solid state.
Knowledge about the absolute configuration of small bioactive organic molecules is essential in pharmaceutical research because enantiomers can exhibit considerably different effects on living organisms. X-ray crystallography enables chemists to determine the absolute configuration of an enantiopure compound due to anomalous dispersion. Here, we present the determination of the absolute configuration of the flavoring agent (+)-gamma-decalactone, which is liquid under ambient conditions. Single crystals were grown from the liquid in a glass capillary by in situ cryo-crystallization. Diffraction data collection was performed using Cu-K alpha radiation. The absolute configuration was confirmed. The molecule consists of a linear aliphatic non-polar backbone and a polar lactone head. In the solid state, layers of polar and non-polar sections of the molecule alternating along the c-axis of the unit cell are observed. In favorable cases, this method of absolute configuration determination of pure liquid (bioactive) agents or liquid products from asymmetric catalysis is a convenient alternative to conventional methods of absolute structure determination, such as optical rotatory dispersion, vibrational circular dichroism, ultraviolet-visible spectroscopy, use of chiral shift reagents in proton NMR and Coulomb explosion imaging.

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