Journal
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
Volume 2017, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2017/3607089
Keywords
-
Categories
Funding
- Bio-industry Technology Development Program through the Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea [315030-3]
- Cooperative Research Program for Agriculture Science & Technology Development through the Rural Development Administration, Republic of Korea [PJ01084302]
Ask authors/readers for more resources
The alpha-glucosidase inhibitor, 1-deoxynojirimycin (DNJ), is widely used for its antiobesity and antidiabetic effects. Researchers have demonstrated that DNJ regulates body weight by increasing adiponectin levels, which affects energy intake and prevents dietinduced obesity. However, the mechanism by which centrally administered DNJ exerts anorexigenic effects has not been studied until now. We investigated the effect of DNJ in the hypothalamus of mice with high-fat diet-induced obesity. Results showed that intracerebroventricular (ICV) administration of DNJ reduced hypothalamic ER stress, which activated the leptin-induced Janus-activated kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT3) signaling pathway to cause appetite suppression. We conclude that DNJmay reduce obesity bymoderating feeding behavior and ER stress in the hypothalamic portion of the central nervous system (CNS).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available