4.5 Article

Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015

Journal

EUROSURVEILLANCE
Volume 22, Issue 31, Pages 13-17

Publisher

EUR CENTRE DIS PREVENTION & CONTROL
DOI: 10.2807/1560-7917.ES.2017.22.31.30586

Keywords

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Funding

  1. Spanish Ministry of Economy, Industry and Competitiveness [AGL2016-74882- C3]
  2. Spanish Ministry of Agriculture and Fishing, Food and Environment
  3. Autonomous Community of Madrid [S2013/ABI-2747]
  4. Junta de Extremadura (Spain)
  5. FEDER (Fondo Europeo de Desarrollo Regional) [GR15075, IB16073]
  6. FCT, Portugal [UID/MAR/04292/2013]
  7. Fundacion Tatiana de Guzman El Bueno (Spain)
  8. Spanish National Institute for Agriculture and Food Research and Technology (INIA) (Ministerio de Economia, Industria y Competitividad) [FPI2014-020]

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Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015. The sequences of both genes hybridised to same plasmid band of ca 250 kb, although colistin resistance was non-mobilisable. The isolate was producing extended-spectrum beta-lactamases and belonged to serotype O-9:H-10 and sequence type ST533. Here we report an mcr-3 gene detected in Europe following earlier reports from Asia and the United States.

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