Journal
EUROSURVEILLANCE
Volume 22, Issue 6, Pages 2-9Publisher
EUR CENTRE DIS PREVENTION & CONTROL
DOI: 10.2807/1560-7917.ES.2017.22.6.30460
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Funding
- British Columbia Centre for Disease Control
- Alberta Health and Wellness
- Public Health Ontario
- Ministere de la sante et des services sociaux du Quebec
- l'Institut national de sante publique du Quebec
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Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network (SPSN) assessed interim 2016/17 influenza vaccine effectiveness (VE) against dominant influenza A(H3N2) viruses considered antigenically matched to the clade 3C. 2a vaccine strain. Sequence analysis revealed substantial heterogeneity in emerging 3C. 2a1 variants by province and over time. Adjusted VE was 42% (95% confidence interval: 18-59%) overall, with variation by province. Interim virological and VE findings reported here warrant further investigation to inform potential vaccine reformulation.
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