Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 28, Pages 6322-6327Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob01113h
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Funding
- National Natural Science Foundation of China [21572196, 21871227]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [BK2013016]
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Functionalized spiro[carbazole-3,5 '-pyrimidines] and spiro[carbazole-3,1 '-cyclohexanes] were efficiently synthesized in satisfactory yields with high diastereoselectivity using CuSO4-catalyzed multicomponent reactions. The initial compounds were further converted to new compounds using different oxidation methods.
Functionalized spiro[carbazole-3,5 '-pyrimidines] and spiro[carbazole-3,1 '-cyclohexanes] were efficiently synthesized in satisfactory yields with high diastereoselectivity by CuSO4 catalyzed multicomponent reaction of indole-2-acetate, aromatic aldehyde and 1,3-dimethylbarbituric acid or dimedone. The reaction was finished with sequential Diels-Alder reaction of both in situ generated indole-2,3-quinodimethane and a dienophile. Additionally, the initially formed spiro[carbazole-3,5 '-pyrimidines] were converted to dehydrogenated spiro[carbazole-3,5 '-pyrimidines] by DDQ oxidation. The initially formed spiro[carbazole-3,1 '-cyclohexanes] were converted to delta-valerolactone-substituted carbazoles by a DDQ promoted Baeyer-Villiger oxidation process.
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