Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 17, Pages 4865-4870Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo00759a
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Funding
- Nanjing Tech University [39837118, 39837146]
- Jiaxing University [CD70520054]
- National Natural Science Foundation of China [22001121]
- Natural Science Foundation of Jiangsu Province [BK20180690]
- Nanjing Forestry University
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The efficient palladium-catalyzed direct reductive cross-coupling reaction proceeds smoothly at room temperature with moderate to good yields, showing reasonable functional group tolerance. The one-pot reaction using readily available aryl bromide as a coupling partner is simple to handle, avoiding the use of pre-prepared organometallic reagents.
An efficient palladium-catalyzed direct reductive cross-coupling of aryltrimethylammonium salts with aryl bromides was developed. The reactions proceeded smoothly in the presence of a palladium catalyst, magnesium turnings, LiCl, and TMEDA in THF at room temperature, leading to the corresponding biaryl compounds in moderate to good yields with reasonable functional group tolerance. The one-pot reaction using cheap and readily available aryl bromide as a coupling partner is simple to handle, thereby avoiding the use of pre-prepared organometallic reagents.
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